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A histogram of AR binding sites residing within the downstream 50 kb or upstream 50 kb genomic regions relative to annotated TSSs is shown in Figure 3.
The intersection of these datasets provides a list of estrogen-responsive transcription factors with high-confidence binding sites residing within two kilobases of each transcription start site for the PCNA gene (Table S2).
Furthermore, FAK has been elaborated to modulate the E26 transformation-specific (ETS) binding site resided within the cyclin D1 promoter, which, in turn, regulates the transcriptional activation of cyclin D1 and leads to promoting cell cycle progression [ 33].
Notably, a small nucleosome occupancy peak at the binding sites indicated that a tiny fraction of binding sites resided on nucleosomes.
We find that the strongest binding sites reside at continuous uridine tracts (U-tracts) of nine or more uridines.
These results suggest that the binding sites reside near and/or inside of the −245 promoter region.
The catalytic center and coenzyme binding site reside within this domain.
Recent experiments have demonstrated that a large fraction of miRNA binding sites reside in coding sequences.
Given that the NS1 RNA-binding site resides wholly within the RBD [37], these data suggest that ability of the NS1 ED to form helix-helix dimers is crucial for efficient RBD activity.
The catalytic residues and substrate binding site reside in a tunnel within a single monomer.
We found that a majority of these STAT6 binding sites also resided within H3K4me3- and H3Ac-positive regions and that pol II was frequently recruited.
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