Sentence examples for binding sites proximal to from inspiring English sources

For a majority of targets, DSBs by an inactive CRISPR Cas nuclease will require at least two guide RNA binding sites proximal to each other on a chromosome.

In the phase-OFF cells, Lrp occupies the binding sites proximal to the transcription start, blocking transcription initiation.

Setting the conservation cut-off to 0.7, we obtained the final 95 putative Sox binding sites proximal to 24 independent genes (additional data file 2).

A secondary phosphotyrosine (pY) binding site, proximal to the active site, has been identified in PTP1B.

10, 11 Recently, a secondary hydrophobic binding site proximal to the primary phosphopeptide binding site has been identified by two independent approaches.

For example, simulations of the HDV ribozyme predict monovalent cation binding at the cleavage site in a crystallographically resolved divalent metal ion binding site proximal to the 5′-O leaving group.

In order to determine whether the gene-specific primer was able to generate PCR product, linker-PCR experiments were carried out using a linker that effectively introduced a PCR primer binding site proximal to the gene-specific primer.

Collectively, these observations indicated that the magnitude of de novo repression of ICP0GFP mRNA synthesis was significantly dependent upon the ICP4-binding site proximal to the transcriptional start site of the ICP0 gene (Fig. 7A).

Thus, it was not surprising for us to find the majority of Hmt1 binding sites fall proximal to or within an ORF.

In this study, we identified several transcription factor binding sites occurring proximal to AhR in the Aroclor 1254-regulated promoters, amongst them NF-kappaB.

In accordance with this, US6 was shown to possess a core domain indispensable for TAP inhibition but not for binding (aa 89 108), and also a site proximal to the ER membrane (aa 116 125) that conferred stability to the TAP interaction and enhanced the inhibitory effect.