Sentence examples for binding sites present on from inspiring English sources

A commercially available compound library (250K+ compounds) was screened against one of the seven allosteric binding sites present on the structure-guided channel model, defined by Leu20, using eHiTS (SymBioSys).

One of the key end-points used in the screening of new molecules, beside the antiproliferative activity, is the binding affinity of the drug to one or another of the specific binding sites present on tubulin.

We identify that BanLec recognizes a subset of high-mannose glycans via bidentate interactions spanning the two binding sites present on each BanLec monomer that were previously considered separate carbohydrate recognition domains.

We therefore conclude that the DCC short isoform shows reduced netrin-1 binding, because it cannot use all possible combinations of the three DCC binding sites present on netrin-1.

For binding sites present on average more than once in each promoter, the forkhead binding site (V$FKHD) was the most significant (p = 0.0044) after V$BRNF, a binding site for POU transcription factors (p = 0.0022).

Carrier molecules are designed for their selective cellular uptake, taking advantage of specific receptors or binding sites present on the surface membrane of the target cell.

The fusion protein could be purified from cell culture medium by protein A affinity chromatography, because there is a staphylococcal protein A binding site present on most VH3 subclasses [ 39- 41].

The antigen binding site, present on the upper tips of the Y shape, is formed by six hypervariable (HV) loops also referred to as the complementary determining regions (CDRs).

Interestingly, that putative binding site partially overlaps with a second isoprenoid binding site present on PFTase previously identified in X-ray crystallographic experiments; in the PFTase catalytic cycle, it has been hypothesized that the isoprenoid group from a nascent prenylated protein is translocated to this second site prior to product release.

This saturation kinetics phenomenon preliminarily noted in the present study (data not shown) indicates that the venom protein(s) may execute their effects via a receptor binding site present on the outer surface of either the fibroblast cell membrane or the double mitochondrial membrane.

Atomic resolution crystal structure of a complex between mGRFT and nonamannoside revealed that a single mGRFT molecule binds to two different nonamannoside molecules through all three carbohydrate-binding sites present on the monomer.