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Theoretical approaches demonstrate efficient and uniform mass transfer of the analyte from the bulk flow to small-scale affinity sensors in the base of fluidic channels by (i) active control of the analyte flow speed over the affinity sensor, (ii) non-rectangular channel geometries and (iii) non-uniform distributions of recognition binding sites over the active area of the sensor.
Langmuir adsorption isotherm is applicable to monolayer sorption onto a surface having homogeneously distributed identical binding sites over the surface sorbent.
The fact that BORIS has multiple isoproteins may enhance the range of potential binding sites over the CTCF target sites.
Mapping the positions of probe binding sites over the known CC5 and CC8 genomes shows that CC5- and CC8-derived genes alternate through the genome suggesting multiple recombination events.
Brendler and colleagues found an even distribution of potential SeqA binding sites over the chromosome [ 34].
In a crystallized receptor-ligand complex, the ligand was extracted from the enzyme, and the binding sites over the whole protein were detected using a multiresidue search.
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Our results suggest a possible mechanism that certain putative zinc finger protein binding sites over-represented in the boundary regions of the methylation-resistant CpG islands may block the spreading of methylation into these islands, and those TFBSs over-represented within the islands may both reinforce the methylation blocking and promote transcription.
In order to identify transcription factor binding sites over-represented in the promoters that are up-regulated during Caco-2 differentiation, promoter sequences from -1350 to +150 were extracted using the UCSC Table browser http://genome.ucsc.edu/.ucsc.edu/
In order to characterize EWS-FLI1 consensus binding sites, over-representation of sequence motifs was searched for.
Here, we do not find Dorsal binding sites over-represented in ZGA vs. non-ZGA CBP peaks.
Promoters enriched in binding to HNF4α were analyzed for transcription factor binding site over-representation using the same procedure (Table 1).
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