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Potential drug binding sites on various polymerases have also been reported.
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ChIP-on-chip [ChIP (chromatin immunoprecipitation) using microarrays] [ 30, 31] is a key approach to globally mapping the in vivo binding sites of various DNA-binding proteins across genomes.
Unresolved is how substrate acyl chains, in either configuration, enter lipid binding sites of various lipoxygenases.
To determine the NLX binding site on FLNA, various overlapping peptides encoding the c-terminal section of FLNA were used to compete for [3H]NLX binding to FLNA using either A7 cell membranes or purified FLNA from A7 or SK-N-MC cells.
Analyses of citrate binding sites on the PFK1 enzymes of various eukaryotic organisms revealed that identical amino acid residues were found at the N-terminus in all examined species (Fig. 1A); however, more variance was observed among the binding sites at the C-terminus.
From our results, we have emphasized the fact that, when these interactions, either positive or negative, are accomplished through transcriptional regulation, the interactions between various binding sites on the promoter need to be taken into consideration.
RTKs function by autophosphorylating on tyrosine residues in their intracellular domain upon activation, often providing binding sites to various proteins containing phospho-tyrosine binding domains.
In the course of this study a number of possible interactions between various cohesin binding sites on the ESR1 gene were tested by chromatin conformation capture analyses.
The promoter region has binding sites for various factors such as SP1 and p300.
The position of the binding sites for various miRNAs differs in paralogous genes.
In addition to binding sites for various transcription factors belonging to different families, polymorphic SINEs showed enrichment for two sites corresponding to CTCF-binding regions.
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