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Taking advantage of the site-directed nature of Tethering, one can investigate the 'druggability' of particular binding sites on a protein surface; furthermore, Tethering has been used to find new binding sites and to stabilize allosteric conformations.
By taking into account the spatial arrangement of binding sites on a target protein, high-affinity multivalent ligands that geometrically complement their target can be designed and synthesized.
The proposed ELISA involved a competitive binding reaction between ROS, in plasma sample, and the immobilized ROS-BSA for the binding sites on a limited amount of the anti-ROS antibody.
Our findings show that, once bound to the ATP synthase, probably through different binding sites on a common binding region on FO, the macrolide antibiotics oligomycin, venturicidin and bafilomycin behave as enzyme inhibitors.
We address this question though the analysis of Atf1 binding sites on a genomic scale using ChIP-chip technology.
Proteins are designed to have new metal binding sites on a backbone template that is not known to have such binding sites [11].
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The effect of the initial dye concentration depends on the immediate relation between the dye concentration and the available binding sites on an adsorbent surface (Gautam et al. 2014b).
The effect of the initial of dye concentration factor depends on the immediate relation between the concentration of the dye and the available binding sites on an adsorbent surface (Salleh et al. 2011).
In the double trapping nanometry (dumbbell assay), preferred binding sites on an actin filament appear every 36-nm along the helix [35].
Here, we treat TFs and their binding sites on an equal footing and so, for example, the substitution rate in each is the same.
Firstly, we calculated the presumed binding efficiency between HR-HPV group and LR-HPV group of each gene (or URR) region roughly: If a miRNA has (at least) one binding site on a gene part in one HPV subtype, we noted the binding situation as 1 (existing), otherwise we noted as 0 (none).
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