It should be pointed out that 16-dextran can interact not only with two antigen-binding sites of single CLL 169 smIg, but also with multiple CLL 169 smIg molecules, since cells express numerous smIgs on their surface.
However, at micromolar concentrations, the Cr III) binds to a low number of saturable tight binding sites on single-stranded M13 DNA.
Our simulations suggest that the time-to-evolve depends in part on the complexity of the combinatorial logic encoded by the CRM, and may be strongly influenced by the requirement for binding sites of a single TF.
The high conservation and length of UCRs compared to binding sites for single transcription factors suggests that the mode of regulation must involve more than the binding of small number of transcription factors.
90%% of these promoters were positive for binding sites of only one single transcription factor: ETS.
They showed the need to explicitly model the evolution of pairs of binding sites, instead of single binding sites, in order to explain relative rates of binding site turnover in invertebrate and vertebrate populations (Aparicio et al. 1995; Ludwig et al. 1998; Swanson et al. 2011) (supplementary note S1, Supplementary Material online).
In the open state, μ2-adaptin is postulated to undergo a large-scale conformational change; this rearrangement brings the four PIP2 binding sites and two endocytic motif binding sites of AP2 into a single plane.
A common characteristic of VHHs is the presence of long CDR3 loops, which confer increase diversity to the binding site of these single domain antibodies.
Large amounts of crosslinking immunoprecipitation (CLIP -seq data (inCLIP -seqITS-CLIP, PAR-CLIP, andataLincludingbeen recently produced to reveal transcriptome-wide binding sites of RBPs at the single-nucleotide level.
Here, we examine the natural DNA-binding sites of the single Drosophila Stat and show that this is not the case.
Schweitzer-Stenner and co-workers showed that dinitrophenol (DNP) units connected by long oligoproline linkers can associate with two antigen-binding sites of a single antibody, though the affinity of this dimer for the antibody was only modestly increased over that of the monomer.
