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The canonical p53 consensus found in many identified binding sites of mostly up-regulated p53 target genes consists of two copies of the palindromic half-site RRRCWWGYYY separated by a spacer of 0 13 bp, in which R = purine, W = A or T and Y = pyrimidine.
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Some xenobiotics are able to bind to the mostly hydrophobic ligand binding sites of SULTs, thereby blocking enzyme activity.
Predicted ligand binding sites of YD1.
The putative binding sites of KmMig1p are shaded.
(B ) The Ca2+ binding sites of LapG.
Short pol III genes with intra-genic factor binding sites are mostly a size of single nucleosomal DNA.
(D) Comparison between adamantane binding site and HMA binding site of HCV p7 channels.
≡SZn denotes the surface binding site of ZnS.
An example binding site patch is shown in Fig. 1 for the cofactor binding site of CDK2 [14].
The binding site of eEF1Bα to domain II overlaps the proposed aa-tRNA binding site.
As a further extension of our study, we are currently analysing splicing isoform-specific expression patterns in combination with our dataset of binding sites, which reside mostly outside disordered regions, in order to understand how isoforms containing a different portion of a structured binding site (or lack thereof) are used in different tissues and/or conditions.
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