Sentence examples for binding sites of human from inspiring English sources
Previously, we have shown that amino-acid sequence changes in the antigen binding sites of human monoclonal aPL are important in determining their ability to bind procoagulant and anticoagulant/fibrinolytic SP, with binding to Thr predicting pathogenicity in mice [ 14].
This study was undertaken to synthesize peptides that are partially similar to the binding sites of human olfactory receptor protein.
An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP.
Molecular dockings of synthesized compounds into the binding sites of human pancreatic α-amylase, intestinal maltase-glucoamylase and neuronal α-butrylcholinesterase allowed to shed light on the affinity and binding mode of these novel inhibitors.
We used docking simulations to calculate their lowest-energy binding conformations within the thyroxine binding sites of human TTR, thereby providing corroborating evidence for their high-affinity binding, and insight into potential binding orientations.
The substrate binding sites of human isovaleryl-CoA dehydrogenase (i3VD), Mycobacterium smegmatis FadE13, pig medium chain acyl-CoA dehydrogenase (MCAD), rat short chain acyl-CoA dehydrogenase (SCAD), and Megasphaera elsdenii butyryl-CoA dehydrogenase (BCAD) were compared using Caver.
We found that since vemurafenib binds to the drug binding site of human ABCG2 with relatively high affinity, it effectively inhibited ABCG2-mediated transport of other drug substrates.
Steady-state kinetic data showed that, at high concentrations, tryptophan can bind to the inhibitory substrate binding site of human IDO in addition to the active site, thereby accounting for the substrate inhibition behaviour of the enzyme [50].
Nuclear proteins from 2008 ovarian cancer cell line treated with TNF-α were able to shift (bind) oligonucleotide sequences containing the predicted NF-κB binding site of human PIK3CA promoter, but were not able to shift either mutant or mock oligonucleotide sequences (Figure 8 D).
To describe the target space, the residues in the binding site of human DHFR (PDB ID: 1OHJ [35]) within a sphere of 10 Å centered around the ligand were selected.
The E4P-bound structure shows that the location of the inhibitor (of cytokine activity) binding site of human AMF is very similar to those of the inhibitor (of enzymatic activity) binding sites of PHIs.
