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However, some protein-DNA interactions exhibit more flexibility and bind their target regions in different configurations resulting in binding sites of different widths.
In addition, a single photoreactive probe incorporated at a unique site in actin nascent chains of different lengths reacted covalently with multiple TRiC subunits, thereby indicating that the nascent chain samples the polypeptide binding sites of different subunits.
I2I-SiteEngine matches chemical functional groups and associated residues at the binding sites of different interfaces.
This information helped us in comparing the ATP binding sites of different DEAD box helicases (Figure 4A).
Most notably, in developmental genes, multiple binding sites of different TFs are often located close to each other in genomes, forming so called cis-regulatory modules (CRMs), and work together to generate precise expression patterns [2].
Different cutoff values correspond to different numbers of putative binding sites of different quality.
Similar(42)
This is accomplished by plasticity, by which a given IDR folds into distinctive conformations to accommodate the diverse binding sites of its different partners (vii) A many-to-one binding mode, by which many different IDPs/IDRs bind to one site on a single ordered partner.
This finding suggest that the promiscuity of ACR is associated with the existence of similar 3D patterns occurring at the binding sites of the different proteins targeted by the drug.
Previously, we reported that the cytotoxicity of 15d-PGJ2 was independent of DP2 and PPARγ, and suggested that 15d-PGJ2 induced apoptosis through the novel specific binding sites of 15d-PGJ2 difroment from DP2 and PPARγ.
In contrast, if the binding sites of two different TFs overlapped, both were counted.
Furthermore, we show that the directionality of these changes can be distinguished by enrichments for the known binding sites of two different groups of transcriptional regulators.
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