Sentence examples for binding sites of both from inspiring English sources
The docking indicates that the inhibitors occupy the binding sites of both G6P and NADP+.
Molecular modeling experiments inside the binding sites of both enzymes were performed.
In this study inhibitors of DAH7P synthase were prepared which were designed to fit into the binding sites of both PEP and E4P substrates simultaneously.
The promoter of G6Pase, a rate-limiting enzyme for gluconeogenesis, contains binding sites of both CREB/CRTC2 (cAMP response element, CRE) and HDAC5/FOXO1 (insulin response element, IRE) (Lan et al., 2007; Liu et al., 2008).
The obtained results highlight the key residues involved in binding sites of both agonists and antagonists, confirming the mutagenesis data and giving new suggestions for the rational design of selective ligands.
With two cholesterol molecules appropriately connected, we hypothesize that the cholesterol binding sites of both proteins will be simultaneously occupied in a manner that will stabilize the protein protein interaction to permit detailed structural analysis of the resulting complex.
The binding site of both cyclooxygenases is highly conserved except for the substitution of an isoleucine at position 523 in COX-1 with a valine in COX-2 [23].
The strong inhibition of warfarin and ANS bound to protein after meloxicam modification compared with aspirin confirms that the binding site of both drugs is not the same.
New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction pattern required for selective inhibition of COX-2 to improve its selectivity against COX-2.
Docking results are consistent with our antimicrobial susceptibility tests and the high-throughput competitive efflux assays performed in this study: All CQAs can successfully enter the binding site of both efflux pumps (Figure 5) remaining in the binding pockets throughout the simulation runs.
