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For example, some proteins interact to form a heterodimer and bind as a complex, in which case the potential binding sites of (all or a subset of) the constituent TFs may be more likely to be physically close to each other.
We found Au10Peptide5 could target to the natural binding sites of all EGFRs at membrane in both active and inactive states by molecular simulations.
At lower pH value, new proton acceptor centers are created and may be competed with metal ions adsorption on binding sites of all phases, resulting in the low adsorption of Cu II) [43].
In our tests, Geomfinder was able to detect identical pairs of 3D patterns (pairs of 3D patterns with a (hbox {GScore} = 100) %) corresponding to the ligand binding sites of all MAO-B structures (Fig. 4).
Next, we constructed a distance matrix comparing the putative binding sites of all possible pairs of OR genes.
We use previously published multiple alignment of OR genes from human and mouse [25] in order to identify the putative binding sites of all OR proteins.
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In such cases, this metal ion occupies all the binding sites of an MT molecule which would otherwise form heterometallic complexes.
The TFBS duplex stability scores are computed for all the binding sites of a promoter sequence.
The binding site of all 8 NNIs was mapped to TP-2 of NS5B as inferred by a decrease in their inhibition potency against the M423T NS5B mutant, employed as a screen for TP-2 site binders.
It has long been known that the binding site of all Cys-loop receptors is dominated by aromatic amino acids.
Sequence analysis showed that the receptor binding site of all of the Nigerian viruses under study retains amino acid residues (Gln 222 and Gly 224).
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