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Long TIR multiple binding sites may offset the negative effect of transposon length.
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The presence of multiple transposase binding sites may somehow offset the penalty associated with increased length of the transposon.
The increase in binding affinity at lower pH was greater for the Ubx optimal binding site than for other DNA binding sites, indicating that subtle sequence alterations in DNA binding sites may influence pH-dependent behavior.
Both binding sites may serve as a template for structure-based design of novel complement therapeutics.
A large fraction of these flanking mutations change overall binding energies by an amount equal to or greater than consensus site mutations, suggesting that current definitions of TF binding sites may be too restrictive.
Similar binding sites often imply similar protein-protein interactions and similar functions; however, similar binding sites may also constitute traps for nonfunctional associations.
The lower affinity binding sites may represent a novel TxR or an alternative affinity state for the previously characterized high-affinity binding site.
These differences in binding sites may be related to the opposite polarity of translocation on MTs of the motors.
The data suggests that the hepatocyte binding sites may be overwhelmed by this dose and/or injection rate of MnDPDP.
Therefore, true binding sites may have SNPs less frequently than the non-binding sites.
Unoccupied 'perfect' STAT1 binding sites may include cell type specific binding sites and suggest a required but not sufficient function of the nucleotide sequence for DNA-protein binding.
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