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Therefore, true binding sites may have SNPs less frequently than the non-binding sites.
Alternatively we cannot rule out that sequence divergence in these samples at primer binding sites may have prevented amplification.
As with the failed attempt to amplify nuDNA from the two relatively recent specimens, an explanation may simply be that sequence divergence in the problematic samples at the primer binding sites may have prevented amplification.
Similarly, some of the annotated binding sites may have been used to construct the PSFM models that we use in our analysis and that in turn can introduce an optimistic bias into our results.
The nucleosome binding sites may have a different distribution between introns and exons in plant genes compared to human genes and this may be a specificity of plant introns favouring the establishment of open chromatin configurations which are typical of genes with high EB.
Therefore, the expression of silMUT, missing these binding sites, may have a similar effect.
Similar(49)
A lost binding site may have been replaced with a new, species-specific binding site - i.e. binding site turnover.
Our observations suggest that metal-binding sites may have been evolutionary selected to achieve optimum allosteric communication.
As water present in the protein crystal structures was deleted prior to virtual screening, ligands that use waters to form interactions with the ATP-binding site may have been missed.
It is possible that the intrusion of the substrate into the metal-binding site may have helped stabilize the open conformation of helix 5, allowing this conformation to be trapped in the crystal.
Consequently, the displacement of T4 by PCB metabolites primarily affects the high-affinity binding site in vivo, whereas both sites may have relevance in the (inter-tissue) transport and retention of xenobiotics.
More suggestions(19)
binding molecules may have
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binding sites may offset
binding sites may be
binding domains may have
binding affinities may have
binding sites may extend
binding sequences may have
binding sites may evolve
binding sites may serve
binding sites may allow
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