Sentence examples for binding sites localized at from inspiring English sources
Considering that nearly 50% of MYC binding sites localized at promoters (Fig. 3a), we analyzed the transcriptional effects of increasing the MYC levels on these loci, in response to its overexpression.
For instance, many large proteins are built from multiple domains with ligand binding sites localized at the interdomain clefts.
In addition to the well-characterized 5' and 3' proximal WREs, at least seven putative binding sites localized to regions far upstream of the MYC transcription start site (Figure 1A, Table S1) [14], [14].
The nucleotide placement of these binding sites coding the amino acid sequence may raise important questions about binding sites localized in the CDSs.
The transcription factor binding sites localized within small hairpin microRNA precursor sequences may possibly regulate their transcription.
However, the mediator binding site is localized at the C-terminal part of Gli3 [17] and the Gli3-PHS like repressor that is generated in vivo is not likely to bind mediator, but may exert its repressor function by an independent mechanism.
These binding sites were mainly localized at enhancers and were enriched for ERα, FOXM1, CREB and ATF3 binding motifs.
These results suggest that GLU A binding sites are localized mainly on the dentate granule cells, whereas GLU B binding sites are localized, in part, on the perforant path fibers, but not on granule cells.
Simultaneously, Gal-3 binding sites were localized around the nucleus of proliferating fibroblast, whereas resting cells only had minimal binding sites in the cytoplasm [ 18].
Many CBP binding sites are localized in sites known as HOT sites which are regions in the genome that bind multiple transcription factors [ 7].
