Sentence examples for binding sites linked by from inspiring English sources

Interestingly, in proteins with multiple binding sites linked by intrinsically disordered regions, observed higher binding rates have been explained by 'a fly casting' mechanism (Shoemaker et al., 2000).

To test this model, we synthesized primed substrate peptides, each containing a C-terminal phosphorylated SH2 domain-binding site, linked by a polyglycine spacer of variable length to an unphosphorylated tyrosine located in a minimal Fes consensus substrate motif.

The 2037 binding sites were linked to 2675 neighbor genes, which were considered ARF6 binding target genes.

We have established a new protein-engineering strategy termed "directed domain-interface evolution" that generates a binding site by linking two protein domains and then optimizing the interface between them.

Moreover, loss of SRSF1 binding sites by mutations linked to genetic diseases can induce aberrant patterns of pre-mRNA splicing [ 5].

Moreover, kinetic-binding assays demonstrated that the sites were linked by negative heterotropic allostery.

Amino acids responsible for TLR-PAMP ligand binding have been shaped for the most part by positive selection, while sites linked to TLR heterodimerisation are conserved.

Transcription factor binding sites are typically linked to their direct target genes.

ZP structure is based on filaments of ZP2-ZP3 heterodimers proteins, linked in some binding sites by ZP1[ 26].

The fact that Prp43 is not specifically recruited to the preribosome can explain why several binding sites are detected by cross-link experiments [ 23].

Dr. Law said that the variant segment linked to schizophrenia had a single DNA unit change at the center of one of the binding sites recognized by the transcription factors that control the gene.