Sentence examples for binding sites is that from inspiring English sources

A third explanation for increased observation of SNPs in the binding sites is that SNPs are involved in altering gene expression during evolution through affecting the binding site sequences.

A further possible explanation for H3Y41ph peaks that do not overlap STAT5 binding sites is that H3Y41ph is laid down by at least one other kinase (Dawson et al., 2009; Griffiths et al., 2011), which may function independently of STATs.

The obvious advantage of using a template containing both LexA and Gal4 binding sites is that co-activator molecules can for example be recruited via Gal4 fusion proteins, such as the commonly used Gal4-VP16 molecule, whereas LexA fusion proteins, such as LexA-Mad, can be used to recruit co-repressor molecules.

Another advantage of disordered filaments as binding sites is that only a little protein is needed to fill a lot of volume a very economical way of having a small amount of protein generate a huge binding site.

A further interesting comparison of convergent sugar-binding sites is that, within fold families, there are often common mechanisms of binding to a core monosaccharide in a primary binding site, but diversity in binding of oligosaccharide and glycoconjugate ligands is achieved through extended and secondary binding sites that are unique to individual members of the family.

Important considerations for designing metal-binding sites are that packing interactions in the binding site should be carefully considered to avoid costly reorganization energies and binding to the unfolded stable should be destabilized (negative design).

The most highly conserved binding site is that of the HIV-1 protease, likely due to the large volume and enclosed shape of the catalytic binding site that enables consistent identification by fpocket and robust detection of similarity by SiteHopper, respectively.

Another feature of the protein metal-binding sites is that the metal ions are often bound to hydrophilic ligands, surrounded by hydrophobic shell or situated in deep hydrophobic cavity [53].

Further evidence for a complex ankyrin-binding site is that peptide-specific antibodies against two different, noncontiguous regions (residues 118-162 and 174-186) both inhibited binding of ankyrin to the anion exchanger and were only 10-20% as effective as antibody against the entire cytoplasmic domain.

The significance of the larger BtMinpp ligand-binding site is that it may permit alternate substrate binding modes.

Overall, multiple candidate transcription factor binding sites were identified that met these criteria (Fig. 4A).