Sentence examples for binding sites is still from inspiring English sources

Computational de novo discovery of transcription factor binding sites is still a challenging problem.

Experimental and computational techniques are interdependent [1], and since traditional experimental techniques for mapping TFBS can be laborious and new high-throughput methods such as ChIP-seq are not readily available or effective in all cell contexts [2], computational prediction of binding sites is still a highly active area of research in bioinformatics.

The distance between the binding sites is still 12 nucleotides.

However, the biological function of these weak binding sites is still unclear.

The identification of transcription factor binding sites is still a challenging and meaningful area.

Although protein-ligand interactions are fundamental to most biochemical reactions, structural information concerning these binding sites is still inadequate.

Furthermore, the functional terms transferase and transmembrane are enriched among HS regulated genes in larvae suggesting that several HS-regulated genes not associated with HSF binding sites are still related in function (Figure 8 compare columns 3 and 4).

To date, knowledge about transcription factor target genes and their corresponding transcription factor binding sites are still very limited.

Due to the relatively promiscuous interactions of these factors (Wolfe et al., 2000), the majority of their cognate DNA binding sites are still poorly resolved.

For bandwidths exceeding 500 bp, performance deteriorates though roughly 90% of the T-KDE-declared constitutive binding sites are still within 500 bp from their nearest motif-based counterpart.

Since the crystallography of certain ligands (e. g. biglycans, hyaluronans and heparin sulphates, ssRNA) [ 44, 68] remains unknown and the precise positions of corresponding binding sites are still missing, our data provide important avenues towards understanding which codons might be candidates for ligand binding residues.