Sentence examples for binding sites is important from inspiring English sources
Thus, the accessibility of their DNA binding sites is important in maintaining pluripotency.
These data suggest that the region −116 to + 36, which includes evolutionarily conserved predicted transcription factor binding sites, is important for basal transcription of ALMS1.
The continuous collar of binding sites is important because substrate binding to three or more adjacent apical domains is essential for productive folding of stringent (strictly GroEL-GroES dependent) substrates (Farr et al., 2000).
We next asked whether the spacing between the two core binding sites was important for FOXP3 DNA binding.
However, it has been shown that both the location and combination of different binding sites are important for promoter recognition [5], [6].
Others have shown that the two p53 binding sites are important for p21Waf1/CIP1 transcription and we have found the same requirement in differentiating keratinocytes (Figure S3).
We found that Sp1 binding sites are important both for basal and hyperosmolarity-induced promoter activities, whereas the NF-κB binding site plays an important role in the hyperosmolarity-induced promoter activity.
Remarkably, the combined mutation of the three intragenic AP-1 binding sites decreased by ∼ two fold the PMA-mediated RNAPII in vivo recruitment to the viral promoter (Fig. 7B, left panel), thereby supporting the notion that the 5103 fragment AP-1 binding sites are important for HIV-1 transcriptional activity.
Because microRNA binding sites are important for mRNA translation and degradation, the variant T allele of rs2016347 might disturb binding to this microRNA site [ 34].
Although individual ascites volumes had no major impact on the variability (data not shown), the number of available binding sites was important.
Between the genomic region of 2 genes, the proportion of STAT1 binding sites of double promoters was higher than other 3 promoter categories, which indicates that these STAT1 binding sites are important in recruiting RPol II for both genes.
