Sentence examples for binding sites is essential from inspiring English sources

Binding of Hox and Pbx family members to bipartite Hox-Pbx binding sites is essential for autoregulation [17], [21], [24], [25].

The results of the present studying validated that the pharmacophoric model with four binding sites is essential for anticonvulsant activity.

Membranes are particularly useful for the separation of large protein molecules (Mw > 250 kDa) where better access to the binding sites is essential (Endres et al., 2003).

Using promoter-luciferase reporter assay combined with mutational analysis of the NKEs we demonstrated that the identified NKX2-5 binding sites were essential for the suppression of β-catenin, and upregulation of GATA4 by NKX2-5.

By serial deletion analysis of the Rad promoter, we identified that two GC-rich early growth response-1 (Egr-1) binding sites are essential for PDGF-induced Rad promoter activation.

A Calcium-dependent characteristic is well known for members of the subtilases superfamily, of which conserved calcium binding sites are essential for enzyme stability and/or activity [ 4].

This surprisingly reveals that transcription factor binding sites are essential to explain the unmethylated state of the majority of CpG islands.

Taken together, these findings indicated that the MDR1 promoter was directly activated by KLF8 and the two KLF8 binding sites were essential for the transcriptional activation of MDR1 promoter.

These findings suggest that the NF-κB binding site is essential to PP2-mediated rescue of activation of the IL-8 promoter in Thy-1+ MEFs.

Some historical studies hold that mutation of the ATP binding site (K270A) abolishes the antiviral function of RIG-I; in other words, the ATP binding site is essential [ 24].

To determine whether the Ser262 tau-MT binding site is essential for Wnt5a evoked axon outgrowth and guidance, we transfected cortical neurons with a tau construct mutated at Ser262.