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Exact(4)
In the case of Irga1 the homology to the exon 1B region of Irga6 continues upstream across the whole region populated by HNF binding sites, while in Irga2 only the distal cluster of HNF binding sites is conserved (Table S1).
The mechanism of replication (DnaA and its binding sites) is conserved throughout the prokaryotic kingdom.
This means that the method does not assume that the location and orientation of binding sites is conserved across species.
While the putative Gab4 contains potential binding sites for SHP2, only one of the three p85 binding sites is conserved and it lacks the typical Grb2 binding site (Fig. 1).
Similar(56)
However, many are based on sequence and overall structural homology [17, 18], consequently often missing similarities when only local binding sites are conserved.
SRY binding sites are conserved among human, mouse and rat.
However, not all binding sites are conserved [29].
These results demonstrate the fact that thresholding-based methods cannot achieve optimal performance since not all functional binding sites are conserved.
In the case of the 152 aa USP, the ligand binding sites were conserved.
Both predicted binding sites are conserved in mammals (Supplementary Fig S1B).
In a bioinformatics study, POU5F1 transcription factor binding sites were conserved among mammalian FZD5 orthologs [ 39].
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