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We used noncovalently bound arrays of bacteriochlorophyll chromophores within native and genetically modified variants of LH1 complexes to monitor local changes in the chromophore binding sites induced by externally applied hydrostatic pressure.
Taken together, the findings suggest that ASA may modify the radioresponse of cultured human hypernephroma cells by preventing the decrease of PG binding sites induced by irradiation.
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For example, binding sites might be able to modulate gene expression as a consequence of differences in affinity (Bain et al., 2012), where high affinity binding sites induce a higher level of transcriptional activation than low affinity binding sites.
The full closure of the degenerated site induced by Mg-ADP binding leads to the asymmetric dimerization of two NBDs (Fig. 5B).
Crystallographic snapshots of glycogenin at different stages of its catalytic cycle were captured, and demonstrated large conformational changes involving a 30 residue 'lid' that covers the active site, induced by UDP-Glc binding [ 44 ].
Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.
On the other hand, Sty1 recruitment primarily occurs at the Atf1/Pcr1 binding sites and is induced by H2O2.
However, many LPS-responsive genes with or without NF-κB binding sites were not induced by Astragalus and suggests alternate modes of gene regulation by the extract.
However, in contrast to the 23% of all genes that map within 1 kb of an ORC binding site in clusters induced by starvation, just 12% of the genes in starvation-repressed clusters similarly map near ORC binding sites (Fig. 2).
Interestingly, XBP1 resides within a non-random starvation-induced cluster of genes, overlaps an ORC binding site and is induced by the orc2-1 mutation [ 5].
Sko1 binds constitutively to some genomic locations, while Sko1 binding at other sites is induced by stress (Capaldi et al. 2008; Ni et al. 2009).
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