Sentence examples for binding sites indicating the from inspiring English sources
Incubation of sulfated PCBs with transthyretin in vitro has resulted in high-affinity binding at thyroid hormone (T4) binding sites, indicating the possibility of transport of these metabolites into the brain and disruption of thyroid hormone homeostasis.
In addition, two samples, initially considered as BPH, but finally diagnosed as harboring PIN lesions were positively stained for membrane testosterone binding sites, indicating the potential diagnostic usefulness of membrane testosterone binding sites identification and/or measurement.
Such conservation of revealed binding sites indicates the possibility of regulator role of miR-548j in PTPN12 gene expression.
(D ) Close-up of the MELTP binding site indicating the role of ScBub1R314 in MELTP binding.
In addition, IL-17RA does not contain a TRAF6 binding site, indicating the existence of another adaptor molecule that mediates TRAF6 association with IL-17RA.
The increase in binding affinity at lower pH was greater for the Ubx optimal binding site than for other DNA binding sites, indicating that subtle sequence alterations in DNA binding sites may influence pH-dependent behavior.
Comparison of these proteins' in vitro binding sites with their in vivo binding sites indicates that PBM-derived specificitiesificanies caccuratelyely reflect in vivo DNA sequence specificities.
Strikingly, examination of the promoters of the upregulated genes revealed an enrichment for E- and D-box binding sites, indicating that the role E- and D-box binding factors play in light induction of the per2 gene might also extend to many other light responsive genes.
However, when considering the down-regulated genes compared to no-change genes, there was also a slight enrichment of STAT1 permuted binding sites, indicating that some of the observed effects may be non-specific (FIGURE S7C).
Location analysis on these ZNF217 binding sites indicate that the cluster II binding sites are largely distal regions, whereas the H3K4me3 enriched cluster I sites are largely promoter proximal (see Additional file 4).
Bioinformatic analysis of the promoter region SNPs for altered transcription factor binding sites indicated that the mutant alleles of all promoter and 5-UTR SNPs are likely to both introduce new transcription factor binding sites and prevent binding of some transcription factors compared to their respective common alleles (TESS).
