Sentence examples for binding sites including the from inspiring English sources

Investigation of neuroendocrine genes has revealed that transcription is regulated via multiple DNA binding sites, including the cyclic AMP response element (CRE).

It is important to note that this deletion removes multiple transcription factor binding sites, including the FUSE binding element known to be required for proper MYC expression [16].

The basic assumption is that many putative binding sites, including the sites of TFexp and of other factors, not just the single best match, may contribute to interaction of this sequence to TFexp.

Specifically, we report the results of virtually screening ∼11,000 diverse fragment-like compounds against a total of 152 protein binding sites, including the training dataset and external dataset studied by Hajduk and coworkers [27].

Thereafter, analysis of the genomic region surrounding the miRNA 17-5p-92 cluster for putative MYCN binding sites (including the canonical E-box CACGTG and the non-canonical sequences CATGTG, CACGGG and CAAGTG) revealed the presence of five MYCN putative binding sites, four upstream and one downstream the cluster (Figure 1C).

53 Other regions of the mRNA can also contain functional miRNA binding sites, including the 5′UTR and the amino acid coding sequence.

Described alternative STAT1 binding sites include the ISRE motif [15] and an additional variant of the GAS motif (M2, [7]).

SCN-enriched genes bearing putative Lhx1 binding sites included the three neuropep-tide genes with the greatest percent reduction in Six3-Cre; Lhx1lox/lox mice (Vip, Prok2, and Nms) as well as Enk, which was not included in our initial analysis.

Other motifs that were enriched in both active and inactive binding sites include the motif of TFAP2α that has been reported to be a co-regulator of p63 (Supplementary Table S7).

Notably, we observed that three of the mutated PyrR residues lie in close proximity to the 5-FU binding site, including the amino acid Val178, which is involved in water mediated hydrogen bonding contact with 5-FU.

Allowing a single mismatch yielded a list of 101 genes with a putative ClgR binding site, including the ATPase clpC1 and clgR itself.