Sentence examples for binding sites in specific from inspiring English sources

In designing right aptamers for interactions with binding sites in specific targets an iterative screening process termed SELEX on complex nucleic acid libraries has been used since its discovery more than two decades ago [ 19, 20].

Examining binding site enrichment patterns in light of transcription factor conservation patterns suggests a second mode via which regulon systems may diverge - rewiring of existing transcription factors and their associated binding sites in specific ways.

In this regard, binding motifs for distinct transcription factors were enriched around the center of STAT binding sites in specific cell types, suggesting that cell-specific gene regulation of STATs might be driven by cooperative activity of cell-type restricted or enriched TFs.

The study describes an effective resource, PlantPAN (Plant Promoter Analysis Navigator), for identifying the co-occurrence of transcription factor binding sites (TFBSs) in a group of gene promoters with distance constraint between two TFBSs, and presents graphically the transcription factor binding sites in specific gene promoter regions of interest.

Additionally, investigation of all the STAT binding sites in different cell types demonstrated that these particular combinations of TFs were not only limited to subsets of the sequences where a given STAT was highly enriched (top 600 sequences) but also could be found in the majority of STAT5 binding sites in specific cell types.

Indeed, we observed specific enrichment and/or depletion of consensus sequence motifs in the cell type-specific regions, such as an overrepresentation of Hox factor consensus binding sites in the HPC7-specific regions, depletion of AP-1 motifs in the HPC7-specific regions and also some specific occurrence of E-box motifs in the mast cell-specific regions (see Fig 4).

In the mosquito Anopheles gambiae (Diptera, Culicidae), a dsx ortholog was previously isolated, and it maintains sex-specific regulation by alternative splicing and putative TRA/TRA-2 binding sites in the female-specific exon [ 18, 19].

The presence of putative Tra-Tra2 binding sites in the female-specific exon of dsx suggests suggest that, as in Drosophila, male-specific splicing represents the default mode and that female-specific splicing requires the Tra-Tra2 complex.

The presence of Tra-Tra2 binding sites in the female-specific exon of dsx pre-mRNA of the Anastrepha species suggests that, in these species, Tra probably also controls the sex-specific splicing of dsx pre-mRNA [28], [29].

The presence of putative Tra-Tra2 binding sites in the male-specific exons and in the surrounding introns may suggest that the Tra2 protein participates in the tra auto-regulatory function.

To test for enrichment of consensus binding sites in the region-specific DHSs, we created sets of DHS peaks that are (1) present in the retina, but not in the cerebellum or cortex; (2) present in the cortex, but not in the retina or cerebellum; and (3) present in the cerebellum, but not in the retina or cortex.