Sentence examples for binding sites in human from inspiring English sources

It is reported that quercetin displaces warfarin bound to human serum albumin [26] due to competitive binding and that genistein also shares the binding sites in human serum albumin with warfarin [27].

Reddy et. al. identified 4,392 GR binding sites in human lung adenocarcinoma cells, A549 [33].

Thus our genome-scale investigation provides evidence for positive selection on putative transcription factor binding sites in human proximal promoters.

Biochemically, DNase I footprinting showed that basonuclin interacted with ribosomal RNA gene (rDNA) promoter at three highly conserved binding sites in human and mouse [22] [25].

This analysis identified 170 genes associated with HARs that display a significant loss or gain of binding sites in human compared with chimpanzee (TFBS divergence) (File S1).

In terms of genomic DNA based experiments, we analyzed five lanes sequencing the PhiX genome using varying platforms, reagents, and read lengths [21], one ChIP-seq lane mapping PAF binding sites in human CD4 cells [22], one ChIP-seq lane mapping CTCF binding sites in human embryonic cells [23], and one lane that served as a control in a ChIP-seq experiment in Jurkat cells [24].

ENCODE has analysed the genome wide distribution of epigenetic marks, chromatin states and of transcription factor binding sites in humans, D. melanogaster and C. elegans.

Concerning the aforementioned, examination of the AP-2ε promoter sequence (−1 to −2999 bp relative to the translation start) revealed four putative HIF binding sites in humans and mice (cf. Figure 2).

Further studies on the effect of quaternary ammoniums on human ether-à-go-go related gene channel inactivation implied that hydrophobic quaternary ammoniums either with a longer tail group or with a bigger head group than tetraethylammonium permeate the cell membrane to easily access the high-affinity internal binding site in human ether-à-go-go related gene channel and exert stronger blockade.

These results support the previous in vitro assay data [13] showing the presence of a CTCF binding site in human 5'HS5 [13].

It should be also pointed out that recent data provide direct evidence supporting the existence of a second substrate binding site in human IDO [50].