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TF are highly context-specific, and the same TF typically binds to different genomic binding sites in different conditions.
Only the longest 3′UTR contains multiple miR-130a binding sites in different species.
In a previous study, quantitative autoradiography [I125] was used to measure cyanolopindolol binding sites in different areas of the brain in ABP and B6 mice [24].
The molecular dynamics simulations studies on a typical complex, AspRS-tRNAAsp showed the specific mode of recognition as well as preferred binding sites in different organisms.
Analysis of the crystal packing shows that the distances between sialic acid binding sites in different knobs are too large to be bridged by a single ME0322 molecule (data not shown).
As the model may predict different levels of the functional importance of specific binding sites in different genomic and regulatory contexts, it is essential to formulate and study such models under different modeling assumptions.
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There are different potential explanations for why adhesion blocking responses were strain-specific, including that the interaction site(s) may differ between VAR2CSA alleles or there may be polymorphism surrounding a related binding site in different VAR2CSA alleles.
The high conservation of catalytic and metal-binding sites in different enolases reflects the essentiality of a common catalytic platform, allowing these enzymes to robustly abstract α-protons of various carboxylate substrates efficiently.
In order to achieve some understanding of the relative importance of selection for and against potential σ70-binding sites in different bacteria, we have analyzed the distribution of −10 σ70 motifs in different regions of 41 additional bacterial genomes (Table 1 and Fig. 2).
Through ChIP-seq mapping of ETS-binding sites in different cell models, we found that the preferences observed for ETS DNA-binding in vitro can contribute to site selectivity in vivo on a genome-wide scale.
Using chromatin immunoprecipitation followed by high throughput sequencing (ChIP-seq), we identified TR4 binding sites in 4 different human cell types and found that the majority of target genes were shared among different cells.
More suggestions(16)
binding sites in diverse
binding events in different
binding sites in relative
binding motifs in different
binding affinities in different
binding elements in different
binding proteins in different
binding sites in genomic
binding sites in synthetic
binding patterns in different
binding partners in different
binding modes in different
binding sites in close
binding sites in mammalian
binding sites in human
binding sites in particular
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