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The notion that transcription factors bind DNA only through specific, consensus binding sites has been recently questioned.
Stabilization of TTR tetramer by ligands which bind to the protein's thyroxine binding sites has been proposed as a treatment for TTR amyloidosis, with drugs such as tafamidis receiving approval for treatment of TTR polyneuropathy and cardiomyopathy.
The existence of GHB high-affinity binding sites has been known for more than three decades, but the uncovering of their molecular identity has only recently begun.
The diffusion of these Zn species induced by transpiration and by exchange with cell wall binding sites has been found to promote light isotopes migration along the transport path [12,71].
A cyclodextrin-based artificial glutathione peroxidase (GPx) system, which was designed to carry single or double binding sites, has been investigated by observing the recognition features of these mimics.
The α1c subunit of the cardiac L-type Ca2+ channel, which contains the channel pore, voltage- and Ca2+-dependent gating structures, and drug binding sites, has been well studied in heterologous expression systems, but many aspects of L-type Ca2+ channel behavior in intact cardiomyocytes remain poorly characterized.
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There are an increasing number of cases in which given, presumably specific, binding sites have been shown to bind a range of ligands with different compositions and shapes.
Multiple nonnucleoside inhibitors (NNIs) binding sites have been identified within the polymerase.
Most commonly, built-in models that assume independent binding sites have been employed in these studies.
Two calix[4]arene derivatives with modified bipyridine as binding sites have been designed and synthesized.
In human postmortem brains [3H]sumatriptan binding sites have been found in among others, globus pallidus > cortex > hippocampus [42].
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