Sentence examples for binding sites from a from inspiring English sources
Two potential protein-ligand binding sites from a total of 10 predicted sites (using Q-SiteFinder) were selected for molecular docking studies.
For example, using ChIP-chip or ChIP-seq experiments, one could identify a set of transcription factor binding sites from a human cell line.
In principle, conversion of a number of available binding sites from a soluble to a more solid or immobile status would be expected to increase the binding of a suitable ligand.
This is particularly relevant for studies involving large data sets that can generate long lists of novel findings such as a list of differentially expressed genes from a microarray experiment or a list of transcription factor binding sites from a ChIP-Seq (chromatin immunoprecipitation followed by sequencing) experiment.
Second, NA exists as a tetramer with four binding sites, the distances between the two glycan headgroups are spaced such that a single molecule could fit into to two binding sites from a single NA tetramer or alternatively, fit into the pockets of two adjacent NA tetramers on a single virion.
The sum of such minima of target required for all ligands of the same binding site from a PMFS is an optimized quantity of the target.
We have developed a computational method to extract implicit structural signatures of a drug binding site from an ensemble of structures of proteins to which this drug binds.
The c3 matrix contained 173 gene sets containing functional motifs conserved in the human, mouse, rat and dog genomes including putative transcription factor binding sites from TRANSFAC, a transcription factor binding site search program and data base, candidate motifs and microRNA target sequences.
A feasible way is to delete the predicted Cbf1 binding sites from the promoter of a Module 5 gene and to evaluate the effects on its expression levels.
In the present study, we compare systematically the current state-of-the-art of detecting transcription factor binding sites from ChIP-seq data under a variety of practical research settings, including reproducibility across biological replicates as well as comparisons to high-scoring binding motifs or independent experimental validations.
