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The promoter region has binding sites for various factors such as SP1 and p300.
The identification of 3D structures and binding sites for various known drugs will guide us for the structure-based drug design of novel compounds as Ang II-AT1 receptor antagonists for the treatment of hypertension.
The Hoxa9 regulatory region may serve as binding sites for various transcription factors and co-regulators to regulate the magnitude of Hoxa9 expression.
The membranes contain prespotted binding sites for various transcription factors in duplicate and two different dilutions annotated by the manufacturer, three of which belong to the ETS family (ETS, ETS/PEA3, EGR).
To identify potential binding sites for various UPR-inducible transcription factors, we analyzed the human, mouse and rat VEGFA promoters using the computer programs rVista and TRANSFAC (Figure S4).
The position of the binding sites for various miRNAs differs in paralogous genes.
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PIP3 acts as a binding site for various intracellular enzymes that contain a pleckstrin homology (PH) domain, such as the serine/threonine kinases phosphoinositide-dependent kinase 1 (PDK1) and protein kinase B (PKB).
The identification of arrestin-binding sites for various signaling molecules will also set the stage for designing molecular tools for therapeutic intervention that may prove useful in numerous disorders associated with congenital or acquired disregulation of GPCR signaling.
The concept of ongoing competition between metallothionein and related proteins with other intracellular metal-binding sites for various metals is also examined in relation to the thermodynamic stability of these proteins.
Surely, one cannot argue that there are no multiple binding sites for the various substrates on CYP and CPO.
The large majority of the binding sites on the p53 sequence map to the disordered regions of this protein, indicating that intrinsic disorder commonly provides the binding sites for the various partners that associate with p53.
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