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However, conventional PCR based SNP analysis methods still require intact primer binding sites for target amplification.
They contain binding sites for target molecules with affinities and specificities on a par with those of antibodies, hormone receptors or enzymes.
Note that both discussed potential interpretations of the GGG-effect give rise to a common cause of the observed small intensity values, namely the reduced number of available binding sites for target binding either via truncation or via complexation of part of the probe oligomers.
The RHR domain contains binding sites for target DNA sequences and other transcription factors.
DNA binding sites for target genes in E. coli K-12 were first collected from different sources (Prodoric, 26 DBTBS, 27 TractorDB, 28 and PDBSum) and afterwards analyzed applying specific perl-scripts and regarding further E. coli strains (E. coli 536, E. coli CFT073, E. coli K-12 W3110, E. coli O157 H7 EDL933, E. coli K-12 MG1655, E. coli O157 H7 Sakai pO157, E. coli UTI89).
Binding sites for target proteins have been also mapped in the N-terminal part of the human Frq/NCS-1protein [ 37].
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It is conceivable that a brief period of transcription is needed to provide nascent transcripts as binding sites for targeting siRNA-associated silencing complex.
All of these domains possess peptide-binding sites for target proteins on the β-sandwich folds.
Few methods for peak calling, however, have incorporated the joint effects of related biological features while detecting binding sites for a target protein.
In this study, we observed significant correlations between mRNA decay rate and the number of miRNA binding sites for miRNA target genes.
While the number of miRNA binding sites for miRNA target genes used in this study ranges from 1 to 173, with average number > 8, more than 82% of genes have 2 or more miRNA binding sites, indicating that majority of miRNA target genes are under multiple miRNA regulation.
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