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ESEs are thought to serve as binding sites for specific serine/arginine-rich (SR) proteins; the SR proteins bind to specific RNA sequences and promote proper exon identification by the splicing machinery (28).
Such transistors might be useful as sensors, by adding binding sites for specific molecules like DNA and proteins that carry electric charges.
The importance of the brainstem for the genesis of migraine is further underlined by the presence of binding sites for specific anti-migraine compounds within these structures [53].
An analysis of the consensus family motifs using the PATCH program in the Transfac database indicated that 19 of the 30 consensus motifs contain sequences that correspond to experimentally confirmed binding sites for specific plant TFs (Table 1).
Match 1.0 uses a library of mononucleotide position specific weight matrices from TRANSFAC® 6.0 to predict candidate binding sites for specific transcription factors [55].
These data encourage speculation that there may be correlation between genes identified by the microarray studies and the binding sites for specific gene products on the UCH L1 promoter.
Similar(34)
By doing so, they act as a binding site for specific miRNAs and functionally inhibit miRNA binding to native targets [101].
The PDZ domain is commonly found in scaffolding proteins where it serves as a binding site for specific peptide sequences in target proteins.
In brief, each Kringle has its unique binding site for specific substrate wherein special function is related to.
This region contains a sequence (cTATGATa) that resembles a K-box sequence present in Drosophila Enhancer of Split gene transcripts (consensus sequence cTGTGATa), which has been reported to be a binding site for specific microRNAs [ 38, 39].
Given a set of known binding sites for a specific transcription factor, it is possible to build a model of the transcription factor binding site, usually called a motif model, and use this model to search for other sites that bind the same transcription factor.
More suggestions(15)
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