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Binding sites for some transcription factors may typically evolve through binding site turnover, whereas binding sites for other transcription factors may often be lost, gained, or exchanged for sites bound by another transcription factor.
Due to the presence of charged moieties, EPS ideally serves as natural ligands providing binding sites for other charged particles/molecules including metals (Guibaud et al. 2005).
In many cases, when a protein adopts an "auto-inhibited" conformation, its active site for substrates, or binding sites for other partners may be blocked and thus this state is also referred to as an "inactive" state; while, in an "active" state, the autoinhibitory conformation is released, making the active or binding sites available for interaction with substrates or regulatory partners.
Among these cis-acting elements are often multiple GR binding sites as well as binding sites for other transcriptional regulators.
Other motifs might represent kinase docking sites [37] or binding sites for other proteins that may cooperate with Cdc28.
This finding provided clues for further analysis of UCH L1 promoter sequence for the presence of putative binding sites for other factors.
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This fortuitous binding site could later prove to be a useful binding site for other low molecular mass partners.
The head module is thought to provide the greatest impact in controlling overall transcription primarily by shifting the transcription machinery from active to inactive state rather than serving as a binding site for other transcriptional regulators.
In these cases, the allosteric-binding site for menthol is also a binding site for other pharmacologically active substances such as the anesthetic propofol (Watt et al. 2008).
However, the presence of a short region of relatively well conserved sequence near the middle of the linker (Fig. 2) suggests a more active role for this region of the domain, perhaps acting as a hinge or as a binding site for other proteins.
Other sites, designated here as 'singletons', correspond to HNF4A occupied sites that are not associated with binding sites for these other factors, although some are also conserved between at least two species.
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