Sentence examples for binding sites for nuclear from inspiring English sources

Our analysis identified an enrichment of binding sites for nuclear respiratory factor 2 (NRF-2), a transcription factor known to play a role in the expression of mitochondrial genes, in the DNA sequences of SIRT3 and genes with closely correlated expression patterns.

Analysis of this sequence revealed presence of many strong binding sites for nuclear effectors of different intercellular signaling pathways.

Other studies using ChIPseq or ChIP on chip to isolate binding sites for nuclear receptors also showed that only approximately 10% of binding sites are located inside of 5 kb from the TSS, whereas the majority of binding sites were located in the intron and/or far distant region [30], [31], [32], [33], [34], [35].

In addition to the previously known C/EBPβ, FOXO1A and ETS1 sites, three potential Hox binding sites were identified in the dPRL enhancer, as well as binding sites for nuclear factor KappaB (NFκB) subunit c-Rel, TG-interacting factor (TGIF), CAAT displacement protein (CDP) and the ubiquitous cofactor Oct-1 (Fig. 1).

It was also found to contain binding sites for nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-1), transcription factors which are well-established mediators of T cell activation, in agreement with the possibility of FOXP3 transcription in activated CD4+CD25lo T cells [11] as well as the fact that Tregs need to be activated in order to acquire suppressor function [23].

Within this sequence many different putative binding sites for nuclear factors were predicted in silico.

Examination of the distal COMT promoter (P2-COMT) reveals a putative binding site for nuclear factor kappaB (NF-kappaB), the pivotal regulator of inflammation and the target of TNFalpha.

While the C −1422 T SNP is not located in a known transcription factor binding site, the T −2521)C SNP and the Δ(−2180 2191) deletion are located directly in the center of a binding site for nuclear factor 1 (NF-1).

Moreover, this promoter polymorphism lies in a putative binding site for nuclear factor-κB, which is known to enhance BAFF gene expression.

These effects at low concentrations of BPA have been explained by the existence of an additional high-affinity BPA binding site for nuclear receptors with inhibitory activity.

Noteworthy is the potential binding site for nuclear factor kappa B/c-rel (NFKB) at the IL1R2 promoter; it is involved in inflammation through several pathways, including IL1 signalization [ 20].