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Structurally, the α subunits of all voltage-gated ion channels consist of a central pore region, which determines channel selectivity and permeability, and four surrounding voltage sensor regions, which include the binding sites for many of the naturally occurring toxins that bind to sodium channels.
GABAA receptors also have binding sites for many other ligand molecules, some of which are widely used therapeutic drugs.
The three-domain design of HSA provides a variety of binding sites for many ligands, including heme and drugs.
The three-domain design of HSA provides a variety of binding sites for many ligands, including heme, bilirubin and drugs.
Since the binding sites for many general TFs are located in the proximal promoter regions of the transcribed gene, it is expected that the DNA double helix of these regions is low, that is, low DNA duplex stability.
The benchmarks on ChIP-characterised factors in yeast and fruitfly suggest strongly that the DWM provides a much-improved representation of binding sites for many transcription factors.
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Upon azurin binding, secondary structure is induced and tryptophan fluorescence is quenched, implying that interactions occur in the N-terminal p53 domain which is also the binding site for many oncogenes.
Some complexes of ABPs and actin have been crystallized, and the binding site for many of these ABPs appears to include a hydrophobic groove located between subunits 1 and 3 at the barbed end [5].
Its main activity product PI 3,4,5) P3 acts as a binding site for many intracellular proteins.
The side pocket has been exploited as a binding site for many highly effective COX-2-selective inhibitors.
The activated form of vinculin primarily localizes to FAs [ 17] where the binding sites for its many partners, including talin and α-actinin (which bind to the head domain), VASP, vinexins, ponsin, and Arp2/3 (which bind to the neck region), and paxillin, F-actin, and PIP2 (which bind to the tail domain) are exposed [ 18].
More suggestions(13)
binding sites for several
binding sites for multiple
binding sites for different
binding motifs for many
binding sites for specific
binding sites for bHLH
binding interfaces for many
binding signatures for many
binding sites for various
binding sites for nervous
binding data for many
binding signals for many
binding ligands for many
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