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With such structural constellation, multiple binding sites for improved affinities are available, resulting in corresponding amplified detection signals.
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While there are binding sites for which analyzing a distribution of alignments improves the accuracy of BigFoot's predictions, for many other binding sites, analyzing a single alignment may return very similar results.
It was recently observed that structural information can be used to improve the prediction of binding sites for DNA-binding or RNA-binding proteins (e.g. [ 17] for DNA-binding proteins, and [ 18, 19] for RNA-binding proteins).
Thus, a better characterization of the thermodynamic properties of GU pairs can improve prediction of secondary and tertiary structure and help predict binding sites for metal ions and target sites for therapeutics.
Darker color depicts more binding sites for the same miRNA.
(A) Location of the binding sites for transcription factors.
We show that naturally occurring binding sites for the Ubx-encoded protein contain clusters of multiple individual binding site sequences.
They also found a loss of RITS binding in clr4− mutants, which lack methylated H3-Lys9 binding sites for RITS.
The first sound evidence for the existence of specific binding sites for THC.
Furthermore two binding sites for bHLH factors were retrieved.
sharing binding sites for miRNAs.
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