Sentence examples for binding sites for important from inspiring English sources

Most polymorphic markers significantly associated with transcription were located in the compact region that was 380 680 bps upstream of the Lim3A major TSS, and were within binding sites for important transcriptional regulators.

Similarly, consensus binding sites for important mesodermal factors such as Twi [CACATGT] [13], Tin [TYAAGTG] [63] and [TCAAGTGG] [64], Mef2 [YTAWWWWTAR] [65], CF2 [RTATATRTA] [66], [67] and PDP1 [RTTTWAYGTAAY] [68] were integrated into our search for cis-regulatory elements regulating duf expression in FCs.

For example, the APP promoter contains binding sites for important TFs, such as purine-rich element binding protein-α (PURα) [ 109] and early growth response 1 (EGR1) [ 110].

Taken together, the functional analysis of the conserved elements within the non-transcribed sequence suggests that these elements harbor binding sites for important trans-acting factors.

The stronger reporter activity is most likely due to the multiple copies of the binding sites for important TFs (Runx2, AP1 etc).. Identification of the 150-bp promoter as the genuine Col10a1 enhancer makes it practical to predict potential TFBS that are functionally important.

Although it is not exactly clear how acetylated histones affect transcription, they might change the structure of chromatin (acetylation of lysine neutralizes the positive electrostatic charge of the histone, facilitating the opening of chromatin) and thereby reveal binding sites for important coactivators.

CNE5 encompasses human to fish 100% conserved contiguous binding sites for developmentally important TFs PBX1, PAX2 and MEIS1.

The UCSC TF database contains the predicted promoter binding sites for many important and well-studied transcription factors and is incorporated into the DAVID gene ontology enrichment tool.

In addition to the formation of the peptide translocation pore, both TAP subunits possess N-terminal segments in their transmembrane domains that contain binding sites for tapasin, important for the stabilization of the TAP dimer and induction of peptide transport.

For example, Boyer et al. have experimentally identified the binding sites for several important transcription factors that affect stem cell identity, including OCT4, SOX2, and NANOG [ 25], and the binding sites of these three transcription factors are found proximal to many transcription factor genes, including themselves, and therefore may form self-regulatory network loops.

Intriguingly, we found that the RNA-binding protein Pum2, a protein that has been recently implicated in the control of dendrite morphogenesis in Drosophila melanogaster (Ye et al, 2004), contains in its 3′UTR multiple potential binding sites for functionally important miR379 410 miRNAs.