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The PPII-structured oligoPro elements are known to provide the binding sites for certain htt-binding proteins, some of which can bind to fibrils.
TESS (Transcription Element Search System) database software allowed assessing of potential binding sites for certain transcription factors in the candidate sequence.
Several have indeed been demonstrated to possess enhancer function (reviewed in [50]) and an enrichment of sequence patterns characteristic of binding sites for certain developmental transcription factors has been found in a large subset of HCNEs [51].
PHA granules with a multifunctional surface displaying both specific binding sites for certain inorganic substances (gold or silica) and for IgG were produced.
One important aspect of this role, crucial to understanding gene regulation [ 46], is the location of the preferred binding sites for certain proteins (transcription factor binding sites or TFBSs).
Leaky expression of viral genes from replication-deficient viral vectors, however, is known to occur due to the presence of binding sites for certain cellular transcription factors in adenoviral promoters [ 43].
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27 This type of consensus profile can be constructed from a set of known binding sites for a certain structural property by many different methods, such as calculating the average profile, averaging specific regions, Fourier analysis or error minimization.
In another assessment, we checked whether the set of target genes containing known binding sites for a certain TF were enriched among the child nodes of that TF in each inferred network.
An example of weak evidence is: expression change detected in a microarray plus existence of a binding site – for a certain TF – detected 'by eye' by the researcher.
These intronic DMRs were significantly enriched for diverse regulatory elements, such as enhancers and binding sites of certain transcriptional factors (e.g., Pol3).
Similarly, genes with constitutive binding sites for other TFs are highly enriched in certain biological processes.
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