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Synthetic polymers, such as polylactide (PLA), polyglycolide (PGA), and their copolymer (PLGA), as well as hydroxyapatite, can be functionalized with serum proteins (e.g. fibronectin or vitronectin), to provide binding sites for cell adhesion (Chastain et al., 2006).
Laponite has been previously reported to provide binding sites for cell attachment and proliferation.
In addition, a decrease in pore diameter is linked to an increase in the specific biomaterial surface, offering a greater density of binding sites for cell attachment.
Second, the large surface area and nanostructure of the material can provide more binding sites for cell receptors, and aid the adsorption and retention of circulating osteogenic factors such as BMPs which contribute to osteogenesis.
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If specific LPS-A549 interactions were occurring free LPS molecules should adhere to their specific A549 receptors reducing the available binding sites for cell-bound LPS, and hence reducing the final cell-associated bacterial count.
(8) Although nephronectin includes an RGD triad as part of its primary structure, early observations pointed to the presence of additional binding sites for cell-surface receptors.
Gelatin films are weaker and smoother than collagen films, with the increased availability RGD sequences in gelatin films providing additional binding sites for cells compared with collagen films.
The ECM must provide both binding sites for cells and mechanical resistance to cellular traction forces (Ingber, 2006; Geiger et al., 2009).
Previous studies have illustrated that the conformation of fibronectin on more rigid substrata is extended, which exposes additional binding sites for cells to fibronectin [ 51].
In the ERM proteins, the head group of PIP2 binds a basic cleft between lobes A and C; this binding displaces the ERM tail from the FERM domain [ 4] thus unmasking the binding site for cell adhesion molecules (such as ICAM1-3 and L1) on lobe C [ 12].
TenC is a highly conserved glycoprotein, mainly expressed during embryonic development and it possesses a multiplicity of binding sites for integrin cell surface receptors, proteoglycans, as well as cell adhesion molecules.
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