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A simple thermodynamic model based on these assumptions shows that in the absence of cooperative interactions, a complex promoter with binding sites for two different repressors should implement a NOR logic, whereas a complex promoter with binding sites for an activator and a repressor should implement an ANDN logic (Fig. 4).
One study combined pocket prediction with evolutionary conservation in order to predict binding sites for an arbitrary small molecule (Huang and Schroeder, 2006).
Furthermore, computational analysis of promoters revealed putative binding sites for an AP-2alpha-like transcription factor upstream of some heat shock induced genes.
This is miRNA-inhibiting transgene which expresses an mRNA which contains multiple tandem binding sites for an endogenous miRNA which is thus able to stably interact with the corresponding miRNA and prevent its association with its endogenous targets [ 142].
The algorithm takes as input the number of binding sites for an arbitrary but fixed transcription factor for each species and a phylogenetic tree of those species with branch lengths.
The necessity for such a mechanism is stressed by the fact that most promoters in multicellular organisms are compound, comprised of several stage- and tissue-specific enhancers that contain multiple binding sites for an assortment of transcriptional regulators.
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This hampers selection of a distinctive reference region lacking binding sites for a tau PET ligand.
We found that binding sites for a transcription factor that makes DNA accessible are required together with binding sites for transcriptional activators to produce a functional enhancer.
The active site is located between the two domains and has binding sites for a zinc ion and substrates l-homocysteine and 5-methyl-tetrahydrofolate-glutamate3.
The environments of the difference peaks are consistent with binding sites for a divalent cation.
Here we provide evidence that exon 23 contains multiple binding sites for a 40 kDa SR protein.
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