Sentence examples for binding sites for additional from inspiring English sources

In contrast, the PORE sequence (Palindromic Oct factor Recognition Element, ATTTGAAATGCAAAT) was originally identified in the first intron of osteopontin (OPN) and cooperatively binds two Oct4 molecules; binding sites for additional transcription factors such as Sox2 and Engrailed were identified in close proximity [10].

It has been postulated that this defines lineage-restricted enhancers and creates binding sites for additional inducible TFs [ 37, 98].

The 5′ end of TERC contains the template region and the 3′ end of TERC contains two binding sites for additional telomerase-associated proteins.

Loss of binding sites may be buffered by the presence of other binding sites for additional factors that are involved in the same process or that bind cooperatively with the factor whose binding site has diverged [ 59].

In breast cancer cells, BCAR1 transcription is directly activated by the early growth response protein 1 (EGR1) in response to phorbol esters, but the presence of putative binding sites for additional transcription factors, such as NF-kB, p53 and HIF, in the promoter region [ 16] points to a more complex control of BCAR1 gene expression.

Next, a methyl scan of the ring was performed to investigate the binding site for additional space (11 13).

The complexity of its structure depends on interactions among conserved amino-acid residues, suggesting a binding site for additional cellular factor(s) not yet identified.

The appearance of novel elements in multiple contexts suggests that they may represent DNA-binding sites for additional factors that are essential for enhancer function.

The availability for additional binding sites for exocytosed AMPAR might thus be dependent on activity- and Zn2+-dependent increases in ProSAP2/Shank3 scaffold proteins at the PSD.

Our new mono-nucleotide and di-nucleotide PWM were able to identify novel binding sites for GATA-3 factor (Additional file 1: Table S1), and some of these sites found experimental confirmation in the previous literature.

For both SREBF1 and LDLR genes, the hypomethylation sites are close to the transcription start site (TSS) and are located near binding sites for PPARγ and C/EBPα (Additional file 1: Figure S4 A and B).