Sentence examples for binding sites for actin from inspiring English sources

Whether PIP2 (Gilmore and Burridge, 1996; Weekes et al., 1996; Hüttelmaier et al., 1998) or actin (Chen et al., 2006) is the preferred partner for talin is yet unclear, but as the binding sites for actin and PIP2 overlap making it unlikely that both bind simultaneously (Steimle et al., 1999).

Lamin A contains several binding sites for actin, at least one of which is lost with progerin truncation [ 40].

Vinculin has binding sites for actin and other proteins such as talin, α-actinin, VASP, Arp2/3, vinexin, nArgBP2 and CAP which can all associate with the actin cytoskeleton.

Overall, mutations in MYH7 are predominantly missense mutations located in the globular myosin head, potentially affecting the binding sites for actin or nucleotides but there are also numerous mutations in the rod region.

EpCAM is a 40 kD type I transmembrane glycoprotein with two epidermal growth factor like repeats in the external domain and a short intracellular domain consisting of two α-actin binding sites for actin cytoskeleton linkage and functions as an intercellular adhesion molecule modulating cadherin-mediated adhesions and thereby adhesion strength [ 9- 12].

As expected, actin (Fig. 3D, lane 5) did not bind to this Myo Va construct (41 326) because the construct lacks the binding site for actin (amino acids 643 666) [32].

Thus, although α-catenin itself has a binding site for actin, bridging the link to actin via vinculin may strengthen this link.

The CD2AP protein contains one binding site for actin, one sequence abundant in proline, and three continuous SH3 (Src homology 3) domains.

Maul et al. [ 15] illustrated that EPLINα has three significant features: EPLINα has at least one binding site for actin and can cross link and bundle actin filaments, EPLINα stabilises actin filaments in vitro, and EPLINα inhibits branching nucleation of actin filaments by the Arp 2/3 complex [ 15].

Merlin/ERM proteins are made up of three structural domains: the amino (N -terminal FERM domaiN -terminalubdivided into three subdomains (FERMF2, andomain thatα-helis domain, and the carboxy (C)-terminal domain, which containsubdividedsus dintothreeding subdomainsctin in ERMs that is absent in merlin.

This study showed that mutations in functionally important domains of the myosin head, including the binding sites for ATP and actin, strongly interfered with assembly of MyHC into thick filaments in body wall muscles [39].