Sentence examples for binding sites existing in from inspiring English sources

AliBaba2 program analysis revealed that there are only AP1 binding sites but not NF-κB binding sites existing in the promoter region of mouse amylin gene.

This suggests that the formation of a preorganized metal-binding site – existing in the wild-type enzyme but not in the W464 mutants – was induced by Im7.

It might indicate a non-CIDR binding site existing on the surface of IRBCs.

Furthermore we re-investigated known binding sites listed in TRANSFAC and found that allowing for gaps in binding sites can sharpen some existing motifs and improve their predictive power.

Although the NarL-DNA interactions have been studied in experiment [ 29- 32], the existing methods for prediction of transcription factor binding sites do not allow for the reliable identification of candidate NarL sites.

However, the majority of binding sites are found in regions of previously accessible chromatin, indicating that (1) RUNX1/Etargetsets binding sites that are destined for differentiation-driven factor exchange, and (2) shortly after its upregulation, C/EBPα resumes its original binding behavior and reorganizes existing transcription factor assemblies to drive myelopoiesis.

A more in-depth understanding of the binding site of existing antagonists opens the door for further rational development of these already effective compounds as P2X7 receptor inhibitors.

Applications on three human TF ChIP-seq datasets demonstrate the advantage of SeqSite for its higher resolution in pinpointing binding sites compared with existing methods.

To validate our computational methods, we constructed a test set of annotated binding sites in mouse promoters from existing databases [13], [33] [35].

One possibility is that dysregulation of histone deacetylation activities after TSA treatment significantly alters the Sox2 binding profile in the genome to a more random state; the other possibility is that TSA treatment redistributes the 3D localization of existing Sox2 binding sites in the nucleus.

Presumably, a ligand-binding site could exist in the groove.