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We evaluated the different gene sets that share a transcription factor binding site defined in the TRANSFAC database enriched in luminal B tumours compared to luminal A tumours.
Gene set C3 (motif gene sets) contains genes that share a transcription factor (TF) binding site defined in TRANSFAC®, a database for transcription factors and their genomic binding sites.
The binding site defined in DS client showed that this cavity could include 216 detector molecules and its volume was 27 Å 3 (with the threshold set at 2.5 Å).
The sequences of predicted EGR2 sites were confirmed by comparison with potential EGR2-binding sites defined in (84) or (85).
The C3 TFT list contains gene sets that share a transcription factor-binding site defined in the TRANSFAC database { http://www.gene-regulation.com}.
We used two approaches for motif search in the Pax8 binding sites defined by MACS.
Number of genome-wide or candidate TFAP2A-modulated human protein-coding genes containing at least one or two high score TFAP2A binding sites defined at various score thresholds (10%, 20 %, 30) in their core promoters.
The proposed approach reveals critical differences in the sets of binding sites defined by the commonly used TFBS models.
(g) All CpGs in both proliferating and arrested ESCs that overlap with OCT4 binding sites (defined by ChIP-seq, ENCODE H1 human ESCs) are displayed.
In addition, the 3D structures allowed the precise delineation of a binding site, defined by highly conserved residues in the vicinity of co-crystallized ligands.
The TCM compounds were docking into the binding site defined above by LigandFit protocol [ 26] in DS 2.5 using a shape filter and Monte-Carlo ligand conformation generation.
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