Sentence examples for binding sites could lead from inspiring English sources

The production of E1A mRNA within hepatocytes that contains multiple microRNA binding sites could lead to the sequestration of mir122 away from its endogenous mRNA targets or depletion of the total mir122 content in the cell.

How ATP hydrolysis at cohesin's ATP binding sites could lead to separation of the hinge domains of Smc1 and Smc3 at the other "end" of cohesin remains a mystery.

First, we tested if strong binding of two antibodies at different sites could lead to background PLA signals from these discrete targets.

We therefore wondered whether other topoisomerase II binding sites could have led to additional differences between the APO-SUS and -UNSUS rat genomes.

To uncover an explanation for how drug binding at a distance from the kinase active site could lead to inhibition and how inhibitors could combine their effects, hydrogen exchange mass spectrometry (HX MS) was employed to monitor conformational effects in the presence of both dasatinib, a clinically approved ATP-site inhibitor, and GNF-5.

For GDI1, residue 92 (Table 1) has been reported to be necessary for the binding and recycling of RAB3 [ 27], and mutations in this site could lead to a reduction in its activity.

It seems possible that the deletion of iron acquisition genes and their Fur binding sites could, in theory, lead to pleiotropic effects by affecting the activation state of Fur or its titration on remaining binding sites.

In [ 28], an essential binding site from ptc1 promoter, with a single substitution from the consensus GBS sequence, was mutated to investigate the effect of change bases in the expression of a reporter gene, resulting in different non-consensus and low affinity Gli binding sites that could lead to transcriptional activation.

For example, new transcription factor binding sites could be created from background sequence through successive adaptive fixations that increase binding site strength; this would lead to an increase in S, and therefore ΔS would be greater than zero on average.

Identification of binding sites could facilitate design of DNA binding ligands for capture and detection of insulin and IGF-2.

Mutagenesis of the predicted binding sites could show if transcription factors are involved in this function.