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The calculated electrostatic interaction energies between various aminoglycosides and their binding sites correlate with experimentally obtained binding free energies.
To validate whether the presence of binding sites correlate with PHA-4 dependence in transcription, we randomly chose 10 genes.
These ligand binding sites correlate with known protein-protein binding interfaces required for oligomerization.
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The decrease of MYC transcriptional activity upon deletion of CTCF binding sites correlates with an increase in the frequency of methylation at CpG residues, consistent with earlier reports of a role for CTCF in the establishment of DNA methylation free domains [2], [25] [27].
EGFR was measured by a ligand-binding assay that quantifies high-affinity binding sites, as we previously reported that EGFR binding sites correlated with anti-EGFR efficacy in vitro (Magné et al, 2002) and that EGFR IHC analysis only partially reflects the presence of functional EGFR quantified with a binding assay (Etienne-Grimaldi et al, 2006).
The dynamics of Htz1 and H3K79me3 around transcription factor-binding sites correlate with transcriptional changes.
It was found to repress transcription of the tumor suppressor gene C/CAAT Enhancer Binding Protein alpha (C/EBPα), and its binding site correlated with upstream methylation of the C/EBPα promoter.
The predicted complex structure of quinazoline inhibitors with EGFR protein from molecular docking provided a stereoview of the binding site correlated with structure activity, affording important information about structure-based drug design.
In our next experiments, we addressed the question of whether the number of CadC-binding sites correlates with the number of clusters.
Recent evidence has shown that impaired miRNA expression or single nucleotide polymorphisms (SNPs) that reside on miRNAs and/or miRNA-binding sites correlate with various human cancers [ 2].
With the exception of the genes PPARG and GR, the number of GR binding sites correlates well with the increase of GR association with the respective gene's TSS.
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CEO of Professional Science Editing for Scientists @ prosciediting.com