Sentence examples for binding sites confirmed that from inspiring English sources
Analysis of the chromosomal position of the identified putative binding sites confirmed that the LacI-family TFs are mostly auto-regulatory and relate mainly to carbohydrate uptake and catabolism.
Additional computational analysis of other categories of single and combinatorial binding sites confirmed that sites co-occupied by Insm1/Neurod1/Foxa2 correlate best with changes in Insm1-dependent gene expression (Supplementary Table S5).
Likewise, impaired mitochondrial accumulation upon doxorubicin and defective transcription-independent apoptosis was also observed in HCT116 p53−/− cells transfected with the p53-M mutant lacking the major Pin1-binding sites, confirming that direct modification by Pin1 alters p53's ability to associate with mitochondria.
There was no significant reduction in luciferase activity following co-transfection with miR-26a mimic and the luciferase reporter vector containing the mutated AMACR binding site, thereby confirming that miR-26a can directly target AMACR.
The results of the ChIP qPCR assay and deletion ESE-1 binding site mutants confirmed that multiple ESE-1 binding sites were available in GP73 promoter.
Therefore, we integrated the heat measurements using a single binding site model, confirming that P. pastoris-produced Ecp6 binds chitin with 1 1 stoichiometry and a dissociation constant (kd) of 4.5 µM.
This lack of ligand binding function confirms that oscillator is a complete loss of function allele.
These results indicate that PAX3-FKHR binds to the promoter region of CPT1A in a PD binding site dependent manner, further confirming that CPT1A is a transcriptional target of PAX3-FKHR.
Binding of Cry1Ac in the resistant insects remains unaltered, confirming that Cry1Ac binding sites are not shared with those of Cry2Ab.
Evidence presented here for the prediction of ori location, is based on the boundary genes and on the in silico finding of characteristic DnaA, CtrA, and IHF binding sites that have been experimentally confirmed only in C. cresentus and partially in R. prowazekii [ 37].
Additionally, we confirm that newly identified low-affinity enhancer binding sites are functional in vivo, and that their contribution to gene expression matches their predicted affinity.
