Our observations that that localized regions of high H3.3 at RNA Pol II binding sites coincide with binding sites of NuRD complex components implies that this class of chromatin remodelers may directly influence the eviction of nucleosomes at TSSs.
Interestingly, several mecamylamine binding sites coincide with the anesthetic binding domains found in the proton-activated ion channel from the bacterium Erwinia chrysanthemi (i.e., ELIC) and in the α4β2-TMD.
The fact that the Arl4A binding site coincided with that of RhoG led to the discovery of a polyvalent RBD in ELMO that demonstrates cross-selectivity for Rho and Arf family GTPases.
On the basis of the protein ligand costructure, the binding site coincides with the predicted inhibition site based on the TIM14 TIM16 complex.
As discussed in the previous section, Crx and Nrl are two transcription factors that play a role in photoreceptor differentiation, and their binding sites coincide extensively with retina-specific DHSs.
Because many of these sites coincided with AP-1 binding sites, the authors suggest that AP-1 expression is triggered by hypoxia and interacts with DNA methyltransferases (DNMTs) to target methylation at specific sites in the genome, causing suppression of the associated genes that are responsible for differentiation of villous cytotrophoblast to syncytiotrophoblast.
Comparison of the sites to the important motifs revealed that the five group-2 sites coincided with the Ca2+-binding motif, which was highly important to caleosin.
Their relationships to four motifs supposed to be functionally important (Ca2+ binding motif, Proline-knot, Tyr kinase-Pi, and CKII-Pi) [ 4] were identified: three sites coincided with the proline-knot motif, eight sites coincided with Tyr kinase-Pi, and two sites were located in the CKII-Pi motif.
In early visual areas, the target sites coincided with the vertical meridian representations of retinotopic maps.
We found that 117 out of 248 HOT sites coincided with cenH3 sites.
