Sentence examples for binding sites at specific from inspiring English sources

Thus, mutation of CTCF binding sites at specific loci may dysregulate the expressions of tumor suppression genes or oncogenes, thereby contributing to the malignant phenotype (Filippova et al., 2002).

Based on these findings, we conclude that the positioning and orientation of transcription factor binding sites at specific distances from the translation start site is a reliable measure to differentiate promoters of genes expressed in different A. thaliana structures from background genomic promoters.

As observed with other transcription factors (see above) expression of ETS was repressed in nuclear extracts of tumor tissues (see Figure 14C) while its DNA binding activity was hardly measurable at predicted TF binding sites at gene specific promoter sequences of Igfbp6 (Figure 14D).

p53 is a transcriptional activator that binds to sequence-specific binding sites at the promoters of several cellular genes and activates their transcription.

We showed that Lbpro possesses specific binding sites at the non prime side from S1 down to S7 [Santos et al. (2009) Biochemistry, 48, 7948 7958].

The above data has so far shown that histone modification at ORFs may be used to predict the functional binding sites at promoters, and that the TF-specific modification of histone lysines disappears at the non-functional binding sites.

These results suggested that miR-136 repressed PPP2R2A through 2 specific 3′-UTR binding sites at positions 149 155 and 712 719.

Our previous studies confirmed that the MYC-MAX binding site at -260/-246 was non-specific [ 16].

CsLTL-1 peptide contains a mannose binding site at 30 99 along with its specific motif of β-prism architecture.

a, 2mFo−DFc electron density map (blue mesh) of residues around the methylguanidinium binding site at 1σ. b, Overlay of guanidinium binding site (green) and methylguanidinium binding site (orange).

Placement enrichment of primate- and human-specific TF-binding sites at selected genomic regions may facilitate chromatin remodeling and transition to the permissive chromatin states (Ernst and Kellis 2013), enabling binding of multiple regulatory proteins and cobinding of many TFs at specific loci (supplementary figs. S9 S11, Supplementary Material online).