Sentence examples for binding sites at high from inspiring English sources

The toxin bound reversibly to α2B-adrenoceptor, but extensive washing was needed for full recovery of binding sites at high toxin concentrations.

In particular, this study revealed that, in spite of matrix sensitivity to proteases (e.g. MMP) and the presence of cell-integrin binding sites, at high stiffness (elastic modulus, G′ >1200 Pa) the matrix acts as a barrier for cells cultured in 3D.

To identify essential origin sequences genome-wide, we utilized a tiled oligonucleotide array (NimbleGen) to map the ORC and Mcm2p binding sites at high resolution.

Further studies showed that the promoter regions of these genes included E-box-containing transcription factor binding sites at higher than expected rates.

Overexpression of c-Myc generally results in increased enrichment (red bars) at endogenous binding sites, although in some promoters we observe overexpressed c-Myc binding at a small number of sites where no or very low endogenous binding signal is detected (e.g. Ebf2, Hes1, Olig3, Gata6) consistent with previously observed occupation of low affinity binding sites at higher Myc levels [27].

This suggests partial deprotonation of the cation binding site at high pH.

By solving the crystal structure of this part of the receptor from zebrafish, Nachtergaele et al. were able to map the oxysterol binding site at high resolution.

Instead of using the DNA that is precipitated with the protein of interest to interrogate microarrays, recent studies have directly sequenced this DNA to analyse the protein-binding sites at high resolution.

The major merit of the proposed SeqSite method is that it can detect binding sites at a high resolution, and can locate closely spaced binding sites.

We developed the method SeqSite that can detect such clustered multiple binding sites at a high resolution from ChIP-seq data.

The novel ChIP technique ChIP-exo can locate binding sites at a higher resolution, but its binding regions identified by ChIP-seq or ChIP-exo experiments may be dozens of bps away from the true binding sites [ 6].